First-principles reasoning
First-Principles Deduction
Reject dependence on familiar paths. Reframe the problem from fundamental mathematical laws and basic axioms.
DeduceX
The Unknown, Extrapolated
At the edge of the knownDeduce the next axiom
01Manifesto · Why We Exist
Human science has long been confined to the circle of the known.DeduceX starts at the circumference and ventures beyond the circle.
From fitting the known to extrapolating the unknown.
Why we existWhy We Exist
For thousands of years, scientific progress has been constrained by the computational limits of the human brain and the physical time required for experimental trial and error.
Today, humanity stands at the boundary of existing knowledge. Fundamental breakthroughs that will shape the future—from new materials and complex biological mechanisms to frontier physics and higher-dimensional mathematics—often lie in scientific territory beyond human intuition and experience.
DeduceX was born from this challenge. We seek to move beyond using AI to interpolate within known data: to extrapolate across dimensions, free people from prolonged blind trial and error, and explore scientific territory that has yet to be named.
Two paradigmsFit vs. Extrapolate
Fit the knownINTERPOLATION
The first generation of AI finds patterns in existing human data. It excels at problems inside the circle but struggles to cross the boundary of that data.
Extrapolate the unknownEXTRAPOLATION
Use AI to move beyond the blind spots of experience, generating hypotheses and testing new principles at frontiers with little or no data.
MissionMission
Build an AI reasoning engine that crosses the boundaries of human experience, explores uncharted science, and accelerates generational advances in fundamental technology.
VisionVision
Become a second scientific brain that expands the reach of human understanding, so that every unknown challenge shaping our future can be reasoned through, tested, and solved.
02Products
First build the brain,
then connect the hands.
Locus Engineering Alpha
Let AI take part in research.
We are building an AI research system that can design, execute, and analyze experiments. The first step is its brain: planning, computation, checks, and retained records, with every step visible.
Explore Locus03Domains · Frontiers of Exploration
Five regions still uncharted.
01 / LIFE & COMPLEX SYSTEMS
Reasoning about Life and Complex Systems
Life Science & Complex Systems
From molecular interactions to cellular networks, living systems span multiple scales and are tightly coupled. We reason about their emergent patterns to identify the nodes that make a difference.
Questions to explore
- Dynamic changes in protein and molecular conformations
- Key nodes in cellular regulatory networks
- Emergence and critical behavior in complex systems
02 / MEDICINE & BIOMEDICINE
Medicine and Biomedicine
Medicine & Biomedicine
From target discovery and drug screening to disease mechanisms, bring candidate approaches to the laboratory sooner, where they can be tested against real data.
Questions to explore
- Screening drug targets and candidate molecules
- Optimizing antibodies and proteins
- Optimizing cell culture conditions
03 / ENGINEERING LIMITS
Next-Generation Deep-Tech Engineering Limits
Engineering at the Limits
Explore feasible designs for next-generation engineering systems near the physical limits of materials, structures, and energy.
Questions to explore
- Structural and topology design under extreme loads
- Shape optimization for efficient flow and heat transfer
- New mechanisms as devices approach physical scale limits
04 / MATERIALS & ENERGY
New Materials and Energy Discovery
Materials & Energy Discovery
Explore materials that have yet to be synthesized in an almost limitless space of compositions and structures, shortening the distance from computation to the laboratory.
Questions to explore
- Candidate structures for energy storage and catalytic materials
- Ion migration and diffusion in crystal lattices
- Inferring macroscopic properties from atomic structure
05 / FUNDAMENTAL SCIENCE
Fundamental Science and Mathematical Frontiers
Mathematics & Fundamental Physics
Seek structures and patterns beyond the reach of intuition in mathematical conjectures, theoretical physics, and complex equations.
Questions to explore
- Uncharacterized geometry and topology in higher-dimensional spaces
- Nonlinear equations and dynamical systems without analytic solutions
- New mathematical conjectures and paths toward their proofs
04Research · Reports from the Frontier
Latest updates
COLUMN 01
Frontier AI in Science and Industry
Follow the latest advances as frontier AI enters scientific research and industry, with our observations and assessments.
Explore the column →
COLUMN 02White Papers on AI Scientific Reasoning
A systematic account of the methods, technical approaches, and evaluation frameworks for moving from fitting the known to extrapolating the unknown.
Explore the column →
COLUMN 03Joint Exploration with Universities and Labs
Choose research questions and test them together with universities, research institutes, and industrial laboratories.
Applications openExpress interest in collaboration →
05Expedition · Into the Uncharted Together
Establish new coordinates where there are no signposts.
Venture into the uncharted
Venture into the Uncharted
Take on difficult, long-term questions in fundamental research beyond established consensus, and establish new coordinates where there are no signposts.
Truth and verification
Rigorous & Verifiable
Scientific exploration has no room for hallucination. Every inference must withstand coherent logical scrutiny and experimental tests in the real world.
Human–AI progress
Symbiotic Discovery
AI does not replace scientists. It gives explorers a telescope and a navigation instrument to see patterns in higher dimensions.
Every great scientific wonder was called impossible before it was deduced.
Every scientific wonder was called impossible, until it was deduced.
Academic exchange
Universities and research institutions with which we have established contact
Capital Medical University 
Peking Union Medical College 
Tsinghua University 
Peking University Health Science Center 
Beijing University of Chinese Medicine 
China Pharmaceutical University 
People's Liberation Army Academy of Military Sciences 
Shenyang Pharmaceutical University